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2 edition of Selected toxicological studies of dimilin in weanling male rats found in the catalog.

Selected toxicological studies of dimilin in weanling male rats

Yogendra M. Patel

Selected toxicological studies of dimilin in weanling male rats

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  • 16 Currently reading

Published by U.S. Environmental Protection Agency, Office of Research and Development, Environmental Monitoring Systems Laboratory, Available to the public through the National Technical Information Service in Las Vegas, Springfield, Va .
Written in English

    Subjects:
  • Insecticides -- Toxicology.

  • Edition Notes

    Statementby Yogendra M. Patel and John A. Santolucito.
    SeriesResearch reporting series -- EPA-600/3-80-031.
    ContributionsSantolucito, John A., Environmental Monitoring Systems Laboratory (Las Vegas, Nev.), Environmental Monitoring Systems Laboratory (Las Vegas, Nev.). Exposure Assessment Research Division.
    The Physical Object
    Paginationvi, 8 p. ;
    ID Numbers
    Open LibraryOL17651571M

    The study by Quast et al. () was selected as 1,1-dichloroethylene metabolites in the lungs of adult and weanling male and female mice: Results of day toxicity study in rats given vinylidene chloride in their drinking water or exposed to VDC vapor by inhalation. Toxicol Appl Pharmacol   E) comprising 5 rats each. Rats in group A served as control, and were administered distilled water per os for 21 days, while rats in groups B, C, D and E were administered oral , , and mg/kg bodyweight of Jatropha gossypifolia leaf extract for 21 days, respectively. At the end of the treatment period, the rats were. # Male # Female Control 0 0/0 5 5 Low / 5 5 Mid / 5 5 High / 5 5 a Data were obtained from pages 18 and of the study report. 3. Dose selection rationale: It was stated that the doses used were suggested by the Sponsor, with 1 mg/kg/day expected to be the NOAEL for the study. Abstract The effects of aqueous extract of Bulbine natalensis Baker stem at 25, 50, and mg/kg of body weight for 14 days on the functional indices of liver and kidney as well as the histology of the rat organs were evaluated. The extract did not significantly (P.


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Selected toxicological studies of dimilin in weanling male rats by Yogendra M. Patel Download PDF EPUB FB2

EPA/ February SELECTED TOXICOLOGICAL STUDIES OF DIMILIN IN WEANLING MALE RATS Yogendra M. Patel and John A. Santolucito Exposure Assessment Division Environmental Monitoring Systems Laboratory Las Vegas, Nevada U.S.

ENVIRONMENTAL PROTECTION AGENCY OFFICE OF RESEARCH AND DEVELOPMENT ENVIRONMENTAL. The rat is one of the most important animal models in toxicology.

This chapter describes the types of toxicological studies and provides information about variables that must be considered in designing toxicology experiments such as rat strain, diet, water quality, intestinal flora, and environmental enrichment.

When a paired feeding study design is to be employed, pairs of litter-mate weanling rats of the same sex and approximate size are selected and fed the control or the experimental diet. As for other control data, published data on reprotoxicology are rare and reports are limited to selected parameters.

51 In contrast, the complete set of data on different study types for the RccHan:WIST rat is available. 12 This rat stock has a high fecundity ( pups per litter) and little variation in reproductive success between the Cited by:   The 30 male neonates were subcutaneously injected in the neck on P1, and five randomly selected rats were dissected on P2, P3, P4, P5, P6, or P7.

The 30 weanling male rats were injected on P35, and five randomly selected rats were dissected on P36, P37, P38, P39, P40, or PCited by: 5. Male laboratory rats were bought locally from veterinary medicine college of animal house. The study was than on 2 groups of saprague dawelly white male rats, untreated control of 20 male rats and 40 male rats of young and adult as treated group.

Control rats feed only on normal. Weanling male rats were dosed by gavage from 21 to 50 days of age with vehicle (% methocel) or chemicals from the following EAC classes: an androgen (testosterone propionate [TP], or mg/kg/day), a broad-spectrum steroid biosynthesis inhibitor (ketoconazole [KETO], 24 mg/kg/day), a 5α-reductase inhibitor (finasteride [FIN], 20 or •The number and types of studies required depend on the therapeutic indication.

• Drugs for life-threatening illnesses require fewer studies to reach the clinic. • In general, animal studies are conducted in two species, one rodent (e.g., rat, mouse) and one non-rodent (e.g., dog, nonhuman primate).

Biologics may require only one species. In a recent in vivo study on weanling male rats, Riad et al. [] reported that TCS, either alone or combined with butylparaben, reduced TSN, leutinizing hormone (LH), and follicle-stimulating. Robert W.

Luebke's research works with 2, citations and 2, reads, including: Host Resistance Assays. A review of studies published or in press.

Cookies on CAB Direct. Dietary protein and pesticide toxicity in male weanling rats. Author(s): Boyd, E. Author Affiliation: Dept. Pharmacol., Queen's Univ., Kingston, Ont. Selected records only. Range eg 1 –– This paper is a review summarizing the results of several years work by the author on the effect of alteration of dietary protein intake on the acute toxicity of pesticides.

Weanling rats were fed on highly purified diets containing varying amounts of casein, or other proteins such as lactalbumin. Low, normal and high protein diets contained %, 26% and 81% casein.

Purchase Male Reproductive Toxicology - 1st Edition. Print Book & E-Book. ISBN According to EPA (), rats selected for these studies should be started on the test material shortly after weaning, ''ideally before the rats are 6 and, in any case, not more than 8 weeks old." For dogs, dosing should begin when they are 4 to 6 months of age and "not later than 9 months of age.".

To investigate the problem, the acute oral LD 50 and the associated clinicopathological syndrome of toxicity were measured in weanling male albino rats fed for 28 days from the time of weaning on diets containing different amounts and different types of proteins.

Initial results suggested that the type of dietary protein was of minor importance. A neurodevelopmental study of the effects of oral ammonium perchlorate exposure on the motor activity of pre-weanling rat pups.

Naval Health Research Center Detachment (Toxicology. Toxicology Studies in Rats, Mice and Guinea Pigs. Sponsor-selected organs are collected, trimmed, and weighed. Organ weights are expressed as absolute, relative to body weight, and relative to brain weight. Additionally, tissues can be examined microscopically by a board certified veterinary pathologist (Dr.

Alison Bendele). You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.

(Unpublished) Effect of dietary administration of DU on reproduction function of one generation in the rat. Huntingdon Research Centre Report no. PDR// (Unpublished) Patel, Y.M.

and Santolucito, J.A. Selected toxicological studies of Dimilin in weanling male rats. The toxicological effects of analytical-grade hexachlorobenzene (HCB) were examined in two chronic studies. Study I was an in utero exposure carcinogenicity feeding experiment in which Sprague-Dawley rats, in groups of 40 males and 40 females except where noted, were fed from weaning on diets containing (64 M/64 F), or (66 M/66 F) ppm HCB.

To provide the basic information needed for studies of drug toxicity in rats suffering from protein deficiency, weanling male albino rats were fed for 28 days on either laboratory chow or a synthetic diet containing 27% or 8% of casein.

The low-protein diet produced a kwashiorkoric cachexia characterized by stunting, alopecia, tail dermatitis. Letter of Aug to Salvatore F. Biscardi concerning protocol for selected toxicological studies of Dimilin in weanling male rats. Philips-Duphar, B.V. March - Selected toxicological studies of Dimilin in weanling male rats.

Excerpt: " Dimilin, at 15,and mg/kg/day, transiently depresses the testosterone in plasma in the prepubertal period, yet has no delaying effects on the development of the reproductive organs.". Multigeneration reproduction studies have been conducted in rats using chlorpyrifos, and developmental toxicity studies have been conducted in mice, rats, and rabbits.

In an oral developmental toxicity study in CD-1 mice, dose levels ranging from to 25 mg/kg/day were administered on gestation days 6– Books.

An illustration of two cells of a film strip. Video. An illustration of an audio speaker. Audio. An illustration of a " floppy disk. Software. An illustration of two photographs.

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Furthermore, the maternal toxicity may have been the trigger for the embryo lethality. The published results of the study of the developmental toxicity of dimethoate in rats indicated that a dose of 30 mg/kg/day produced high mortality rates in dams and was not considered for developmental evaluation (Srivastava and Raizada, ).

Those. Toxicological studies (a) Short-term toxicity Rats Groups of 49 male and 49 female Charles River rats (strain Crl:(WI)BR; weeks of age) received lindane (purity, %) formulated in 5% aqueous carboxymethylcellulose as dermal applications on the clipped dorsal skin under occlusive conditions for 6 h per day on five consecutive days per.

Gum ghatti, a polysaccharide of natural origin, is used in foods as a thickening, gelling, emulsifying and stabilizing agent. In a day toxicity study following Organization for Economic Co-operation and Development (OECD) Guideline #, male and female Sprague–Dawley rats were exposed to 0 (control),and 5% gum ghatti in AINM basal diet.

In the only animal study investigating the carcinogenic potential of inhaled aluminum compounds, there was no evidence of an increased incidence of tumors in the lungs of male or female Wistar rats exposed to aluminum fibers (â mg aluminum/m3; 96% aluminum oxide) for 86 wk (Pigott et al.

Long considered the definitive test of reproductive toxicity is the two-generation reproduction toxicity study (OECD TG ), which involves continuous dosing of parental rats and their offspring with the test substance (usually in the diet, but other routes are possible) for two entire generations, up through weaning of the F2 pups at 3 weeks.

The aims of reproduction toxicology studies ICH Guidelines The basic reproductive cycle How certain drugs can affect the cycle In this presentation we will cover Study designs • Usually conducted in rats • May be done separately –male or female fertility assessment –or together • Also known as Segment I study 1.

Fertility and. ANIMAL USE IN TOXICITY STUDIES Animal use in toxicity studies Introduction In this chapter we describe the purpose and principal methods of toxicity studies.

Most of these studies are conducted to assess the degree to which substances are toxic (poisonous) for humans, animals or the environment, to investigate the mechanism of toxic.

In a subchronic toxicity study male Sprague-Dawley rats were daily treated with diisopropylphosphorofluoridate (DFP) ( mg/kg, sc) for 14 days. Maximum signs of anticholinesterase toxicity were observed during Days 4 and 5 comparable to those seen min following a single sublethal dosage ( mg DFP/kg, sc).

Trachurus trachurus (locally called kote) is a table fish that has become increasingly important in the Nigerian diet because of its low price.

Therefore, this study investigated the effects of processed kote on the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in selected tissues of weaned male albino rats using standard methods.

Adult Male, Rat. Adult male Wistar rats (12/dose) were administered endosulfan by gavage for 7 or 15 days at 0 (groundnut oil),or 10 mg/kg/d to investigate gonadal toxicity (Singh and Pandey, a). After 7 or 15 days of treatment, 6/dose were terminated. The present study was designed to evaluate the influence of acrylamide (ACR) on male and female reproductive function.

Male rats received ACR in drinking water (50,or ppm) for up to 10 wk. Copulatory behavior, semen, and (for controls and ppm only) fertility and.

Impact of lead toxicity on male rat reproduction at “hormonal and histopathological levels”. Toxicological & Environmental Chemistry: Vol. 92, No. 4, pp. toxicity trace elements trace metals life-term studies \Ve have exposed weanling rats and mice to each of some 21 to 29 "abnormal" trace elements for life in order to ascertain recondite toxicity (1).

The present report concerns aluminum, barium, beryllium, arid tungsten given as soluble salts in drinking water to rats. *Brodeur J, DuBois KP. Comparison of acute toxicity of anticholinesterase insecticides to weanling and adult male rats.

Proc Soc Expl Biol Med *Butler PA, Schutzmann RL. Fish, wildlife, and estuaries: Residues of pesticides and PCBs in estuarine fish, National Pesticide Monitoring Program. Pestic Monit J 12(2. Repeat-dose toxicology studies in minipigs are conducted in the same way and using the same end points as for toxicology studies in dogs or primates, as also briefly described above in the section on dermal toxicology studies.

A more detailed account of dosing methods employed in minipigs can be found in the study by Clausing. Hydrolysis of selected organophosphorus insecticides by two bacteria isolated from flooded soil. et al. The Agricultural Health Study.

Environ Health Perspect (4) Altman PL, Dittmer DS. Boyd EM. Dietary protein and pesticide toxicity in male weanling rats. Bull World Health Organ 40(5)  Numerous toxicological studies report adverse effects on thyroid function [9,10,11,12,13,14,15,16], on reproductive organ development notably in male rats, decreased testosterone and sperm production [17,18,19], lowered pup bodyweight, early age of pubertal onset [15, 20] and increased uterine weight [15, 21].Books to Borrow.

Top Full text of "NTP technical report on the toxicology and carcinogenesis studies of barium chloride dihydrate (CAS no. ) in F/N rats and B6C3F́ mice (drinking water studies)" See other formats.